The NSF Career Awards are extremely competitive and prestigious grants for pre-tenure faculty. Congratulations Jane!
CAREER: A New Data-Driven Network Inference Framework for Identifying Context-Specific Protein Interaction Graphs
The past decade has seen a revolution in genomic technologies that enable the simultaneous measurement of thousands of molecular entities (e.g., genes or proteins). This flood of genome-wide data has provided an unprecedented coverage of large-scale, context-conditioned signatures of relevant entities that have great potential to infer network connectivity and function under each context. This proposal will develop a suite of novel and efficient machine-learning methods for inference of context-specific networks from multi-context molecular signature datasets that are high dimensional, heterogeneous and noisy.